When police raid a house in El Paso, they find it full of dead Latinos, and only one survivor. Known as "The Traveler," he is taken to the police station for questioning. There, he recounts tales of horrors from his life, chronicling portals leading to other worlds, mythical beings, demons and the undead; he speaks of legends from Latin America. Satanic Hispanics tells stories by top Latin filmmakers that showcase the skills of Hispanic talent, both on and off screen.

When a giant alien spider escapes from a military lab and rampages across the city of Los Angeles, it is up to one clever exterminator and his security guard sidekick to kill the creature before the entire city is destroyed.